Associate Principal Investigator (NIBRT)

Contact
Phone:+353 (01) 2158100
Fax:+353 (01) 700 5484
Email: colin.clarke@dcu.ie; Colin.Clarke@nibrt.ie

Awards

  • SFI Starting Investigator Research Grant (SIRG) Award 2014
  • Martin Sinacore Outstanding Young Researcher Award 2014
  • Best Oral Presentation at the 2014 DCU School of Biotechnology Research Day
  • Cranfield University Bioinformatics MSc. course team prize 2003/2004 academic year.

Academic Background

  • PhD Bioinformatics Cranfield University 2009
  • MSc Bioinformatics Cranfield University 2004
  • BSc Biology WIT 2003

Principal Research Interests:

  • Bioinformatics
  • Biotechnology
  • Machine learning
  • Multivariate statistics
  • Biostatistics

Selected Publications

  1. Kelly, P. S., Clarke, C., Clynes, M., Barron, N., Bioprocess engineering: micromanaging Chinese hamster ovary cell phenotypes. Pharmaceutical Bioprocessing 2014, 2, 323-337.
  2. Doolan, P., Clarke, C.*, Kinsella, P., Breen, L., Meleady, P., Leonard, M., Zhang, L., Clynes, M., Aherne, S.T. and Barron, N. (2013) Transcriptomic analysis of clonal growth rate variation during CHO cell line development. J Biotechnol, 166, 105-113.
  3. Clarke, C., Madden, S.F., Doolan, P., Aherne, S.T., Joyce, H., O'Driscoll, L., Gallagher, W.M., Hennessy, B.T., Moriarty, M., Crown, J. et al. (2013) Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis. Carcinogenesis, 34, 2300-2308.
  4. Clarke, C., Henry, M., Doolan, P., Kelly, S., Aherne, S., Sanchez, N., Kelly, P., Kinsella, P., Breen, L., Madden, S.F. et al. (2012) Integrated miRNA, mRNA and protein expression analysis reveals the role of post-transcriptional regulation in controlling CHO cell growth rate. BMC Genomics, 13, 656.
  5. Clarke, C., Doolan, P., Barron, N., Meleady, P., Madden, S.F., DiNino, D., Leonard, M. and Clynes, M. (2012) CGCDB: a web-based resource for the investigation of gene coexpression in CHO cell culture. Biotechnol Bioeng, 109, 1368-1370.
  6. Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M. and Clynes, M. (2011) Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity. J Biotechnol, 155, 350-359.
  7. Clarke, C., Doolan, P., Barron, N., Meleady, P., O'Sullivan, F., Gammell, P., Melville, M., Leonard, M. and Clynes, M. (2011) Predicting cell-specific productivity from CHO gene expression. J Biotechnol, 151, 159-165.
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