Phone:+353 (01) 7005401
Fax:+353 (01) 700 5484
B.Sc. NUI, Galway
M.Sc. University of London
Ph.D. Dublin City University
Principal Research Interests
Identification and investigation of novel membrane protein targets that are highly expressed in cancer for potential Monoclonal Antibody (MAb) therapeutic targeting using Antibody Drug Conjugates (ADCs).
Development of anti-invasive MAbs using functional hybridoma screening approaches to identify novel drug targets for MAb mediated inhibition of cancer invasion.
Cancer Invasion and Drug Resistance.
Dowling P, Hughes DJ, Larkin AM, Meiller J, Henry M, Meleady P, Lynch V, Pardini B, Naccarati A, Levy M, Vodicka P, Neary P, Clynes M. Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer. Clin Chim Acta. 2015 Feb 20;441:133-41. doi: 10.1016/j.cca.2014.12.005.
Linge A, Maurya P, Friedrich K, Baretton GB, Kelly S, Henry M, Clynes M, Larkin A*, Meleady P *. Identification and functional validation of RAD23B as a potential protein in human breast cancer progression. Journal of proteome research Jul 3;13(7):3212-22. doi: 10.1021/pr4012156. Epub 2014 Jun 19. (*joint senior author)
O’Sullivan D, Henry M, Joyce H, Dowling P, Mc Auley E, Walsh N, Barnham P, Clynes M, Larkin A. 7B7 – A novel antibody directed against the Ku70/80 heterodimer blocks invasion in lung squamous and pancreatic cancer cells. Tumour biology 2014 Apr 18.
Linge A, Kennedy S, O'Flynn D, Beatty S, Moriarty P, Henry M, Clynes M, Larkin A*, Meleady P*. Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not. Invest Ophthalmol Vis Sci. 2012 Jul 9;53(8):4634-43. doi: 10.1167/iovs.11-9019. (*joint senior author).
Walsh N, Kennedy S, Larkin AM, Tryfonopoulos D, Eustace AJ, Mahgoub T, Conway C, Oglesby I, Collins D, Ballot J, Ooi WS, Gullo G, Clynes M, Crown J, O'Driscoll L.. (2010).
Walsh N*, Larkin A*, Kennedy S, Connolly L, Ballot J, Ooi W, Gullo G, Crown J, Clynes M, O’Driscoll L. Expression of Multidrug Resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in Renal Cell Carcinoma. BMC Urology, 2009;6:9.
Matthews C, Catherwood MA, Larkin A, Clynes M, Morris TCM and Alexander HD. MDR-1, but not MDR-3 gene expression is associated with unmutated IgVh genes and poor prognosis chromosomal aberrations in chronic lymphocytic leukaemia. Leukaemia and Lymphoma, 2006; 47:2308-2313.
Larkin A, Moran E, Kennedy SM and Clynes M. Monoclonal antibody 5C3 raised against formalin fixed paraffin-embedded invasive breast tumour tissue: characterisation of its reactive antigen via immunoprecipitation and internal sequencing. J Immunol Methods, 2005; 303:53-65.