Associate Director, NICB.

CHO Cell Proteomics; Uveal Melanoma

Proteomics Core Facility Programme Leader

 

Research Groups

CHO group

Contact

Phone:+353 (01) 7005910
Fax:+353 (01) 700 5484
Email: paula.meleady@dcu.ie

Academic Background

BSc Biotechnology, DCU

PhD in Cell Biology, DCU

Principal Research Interests

Proteomic and phosphoproteomic profiling of recombinant mammalian cell lines (Chinese hamster ovary) in order to gain insights to improving productivity of biopharmaceuticals.

Proteomic analysis of uveal melanoma from both tissue and vitreous fluid for biomarker discovery. This project is in collaboration with Prof. Susan Kennedy, Royal Victoria Eye and Ear Hospital, Dublin.

Membrane proteomics of pancreatic cancer

Proteomics of serum/plasma from clinical samples for biomarker discovery

Selected Publications

  1. Di Luca A, Henry M, Meleady P, O'Connor R. (2015) Label-free LC-MS analysis of HER2+ breast cancer cell line response to HER2 inhibitor treatment. Daru. 2015 Aug 4;23:40. doi: 10.1186/s40199-015-0120-y.

  2. Holland A, Henry M, Meleady P, Winkler CK, Krautwald M, Brinkmeier H, Ohlendieck K. (2015) Comparative Label-Free Mass Spectrometric Analysis of Mildly versus Severely Affected mdx Mouse Skeletal Muscles Identifies Annexin, Lamin, and Vimentin as Universal Dystrophic Markers. Molecules. 2015 Jun 19;20(6):11317-44. doi: 10.3390/molecules200611317.

  3. Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N. (2015) Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype. Biotechnol J. 2015 Jul;10(7):1029-40. doi: 10.1002/biot.201500101. Epub 2015 Jun 24.

  4. Holland A, Dowling P, Meleady P, Henry M, Zweyer M, Mundegar RR, Swandulla D, Ohlendieck K. (2015) Label-free mass spectrometric analysis of the mdx-4cv diaphragm identifies the matricellular protein periostin as a potential factor involved in dystrophinopathy-related fibrosis. Proteomics. 2015 Jul;15(13):2318-31. doi: 10.1002/pmic.201400471. Epub 2015 Apr 1.

  5. Ramasamy P, Murphy CC, Clynes M, Horgan N, Moriarty P, Tiernan D, Beatty S, Kennedy S, Meleady P. (2014) Proteomics in uveal melanoma. Exp Eye Res. 2014 Jan;118:1-12. doi: 10.1016/j.exer.2013.09.005. Epub 2013 Sep 19.

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