Uveal Melanoma Research Using Proteomic Methods
Uveal melanoma is the most common intraocular malignancy in adults. The survival rate of uveal melanoma patients who develop metastatic disease is very poor, with few therapeutic options available to treat advanced disease. We are using proteomic methods, e.g. quantitative label-free LC-MS, to understand progression of metastasis in uveal melanoma, using both tissue and vitreous fluid samples from patients with uveal melanoma. This research is being carried out in collaboration with Prof. Susan Kennedy at the Royal Victoria Eye and Ear Hospital, Dublin.
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- Ramasamy P, Murphy C, Horgan N, Clynes M, Kennedy S, Meleady P. (2014) Proteomics in uveal melanoma. Exp Eye Res. 2014 Jan;118:1-12.
- Linge A, Kennedy S, O'Flynn D, Beatty S, Moriarty P, Henry M, Clynes M, Larkin A, Meleady P. (2012) Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not. Invest Ophthalmol Vis Sci. 2012 Jul 9;53(8):4634-43.