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Two PhD Studentships in Biopharmaceutical Proteomics
The National Institute for Cellular Biotechnology (NICB) located at Dublin City University (DCU) is seeking two highly enthusiastic PhD students to conduct research in proteomics of recombinant mammalian cells used in biopharmaceutical production.
Project Description & Background: The Chinese hamster ovary (CHO) cell line is the dominant mammalian expression system for biopharmaceutical production. Improving the efficiency of production of complex biotherapeutics will be critical in controlling costs to healthcare systems as more of these drugs come to market. In CHO production cell cultures, the expression of high levels of recombinant biopharmaceuticals is linked to inducing endoplasmic reticulum (ER) stress, causing enhanced unfolded protein response (UPR) levels to maintain cell viability and productivity. ER stress mechanisms are poorly understood in CHO cells, and are a major bottleneck in improving the efficiency of production of high cost recombinant biopharmaceuticals. Advanced nano high performance liquid chromatography separation, high-resolution state-of-the-art mass spectrometry and data analysis will be used to identify proteomic changes and site-specific post translational modifications (e.g. ubiquitination, phosphorylation) on cellular proteins as a result of changes to productivity of CHO cells. This will lead to a better understanding of functions of proteins and their place in complex CHO biological systems for the identification of engineering targets to improve cell productivity that is of significant relevance to the Biopharmaceutical industry.
Location: National Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
Applicant Requirements: We are seeking two highly enthusiastic PhD candidates to join this Science Foundation Ireland (SFI) funded research project. Applicants should have a first or upper second-class honours Bachelor’s or Master’s degree in a relevant field. Excellent written, oral communication skills and a high level of competence in the English language are essential. (See DCU’s policy on minimum English language requirements ).
Stipend & fees: The successful candidates will receive a stipend of €18,500 per annum. €5,500 will be available towards registration fees per annum. The positions are fully funded for four years. The positions will commence from 1st December 2020.
Application procedure: Applicants should forward a cover letter, CV with full details of academic qualifications and experience to date, and names of two referees, as a single .pdf document to email@example.com.
Application deadline: 19th October 2020.
This information is available as a download here