Main area of research is in the role of cellular and molecular studies in the diagnosis, classification and risk stratification of haematological malignancies. Long-term commitment to translational research, in particular the speedy implementation in clinical practice of advances made through research in the understanding of the biology of haematological malignancies, their risk stratification, and treatment strategies informed by objective, scientific, imaging and clinical criteria. Current studies include the molecular genetics of chronic lymphoproliferative disorders, with particular emphasis on IGHV mutational status and gene usage, multidrug resistance, and the possible role of auto-antigens, infective agents and inflammation in the aetiology of these disorders. Supervised many MSc and PhD research projects and acted as external examiner for primary degrees and postgraduate research degrees including PhD, MPhil/PhD transfer and MSc.
Prof. H Denis Alexander
Six patients with rare blood disease are doing well after gene therapy clinical trial. Treatment uses person’s own #stemcells instead of donor cells. http://ow.ly/gSUp30qd0cL