Research Fellow,

Cell Biology In Vitro modelling

Research Groups

Stem Cell/Differentiation Group


Phone Number: 01 700 8922

Email Address:


Biographical Details

Principal research interests:

  • In Vitro cell modelling to study trace element impact on uptake, protein, gene and miRNA expression

Selected Recent Publications:

  1.  Keenan J, O'Sullivan F, Henry M, et al. Acute exposure to organic and inorganic sources of copper: Differential response in intestinal cell lines. Food Sci Nutr. 2018;6(8):2499-2514.
  2. Keenan, J., Horgan, K., Clynes, M. et al. Unexpected fluctuations in trace metal levels in cell culture medium in vitro; caveat emptor. In Vitro Cell.Dev.Biol.-Animal (2018) 54: 555.
  3. O'Sullivan F, Keenan J, Aherne S, O'Neill F, Clarke C, Henry M, Meleady P, Breen L, Barron N, Clynes M, Horgan K, Doolan P, Murphy R. Parallel mRNA, proteomics and miRNA expression analysis in cell line models of the intestine. World J Gastroenterol. 2017 Nov 7;23(41):7369-7386.
  4. White MM, Geraghty P, Hayes E, Cox S, Leitch W, Alfawaz B, Lavelle GM, McElvaney OJ, Flannery R, Keenan J, Meleady P, Henry M, Clynes M, Gunaratnam C, McElvaney NG, Reeves EP. Neutrophil Membrane Cholesterol Content is a Key Factor in Cystic Fibrosis Lung Disease. EBioMedicine. 2017 Sep;23:173-184.
  5. Keenan J, Joyce H, Aherne S, O'Dea S, Doolan P, Lynch V, Clynes M. Olfactomedin III expression contributes to anoikis-resistance in clonal variants of a human lung squamous carcinoma cell line. Exp Cell Res. 2012 Mar 10;318(5):593-602.

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