Assistant Professor and Research Scientist

Research Groups

T-cell signalling group

Contact

Phone: +353 1 700 5961
Email: michael.freeley@dcu.ie

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Principal Research Interests

My research focuses on the cell biology of the T-cell immune response, particularly the genes and signalling pathways that T-cells use for migration and activation.

I have used several functional approaches to elucidate these pathways, including RNA interference (RNAi), screening of RNAi libaries and High Content Image Analysis.

The translational aspect of my research aims to understand how these pathways may be manipulated for the treatment of autoimmune/inflammatory diseases, infectious diseases and cancer (immunotherapy).

Selected Publications

  1. Dunne PJ, Maher CO, Freeley M, Dunne K, Petrasca A, Orikiiriza J, Dunne MR, Reidy D, O'Dea S, Loy A, Woo J, Long A, Rogers TR, Mulcahy F, Doherty DG. (2018) CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection. Front Immunol. 2;9:940.
  2. Verma NK, Fazil MH, Ong ST, Chalasani ML, Low JH, Kottaiswamy A, P P, Kizhakeyil A, Kumar S, Panda AK, Freeley M, Smith SM, Boehm BO, Kelleher D. (2016). LFA-1/ICAM-1 Ligation in Human T Cells Promotes Th1 Polarization through a GSK3β Signaling-Dependent Notch Pathway. J Immunol. 2016 Jul 1;197(1):108-18.
  3. Freeley M, Derrick E, Dempsey E, Hoff A, Davies A, Leake D, Vermeulen A, Kelleher D and Long A. (2015) RNAi screening with self-delivering, synthetic siRNAs for identification of genes that regulate primary human T cell migration. Journal of Biomolecular Screening 20(8): 943-956.
  4. Freeley M and Long A. (2013) Advances in siRNA delivery to T cells: potential clinical applications for inflammatory disease, cancer and infection. Biochemical Journal 455(2): 133-147. Review.
  5. Freeley M, O’Dowd F, Paul T, Kashanin D, Davies A, Kelleher D, Long A. (2012). L-plastin regulates polarisation and migration in chemokine-stimulated human T lymphocytes. Journal of Immunology 188(12): 6357-70.

 

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